Cannabis is one of the most maligned plants worldwide. It is mostly known for inducing psychoactive effects. Moreover, in recent years, more and more people are starting to recognize its medicinal value. However, the intoxicating high delivered is often a hindrance to patients seeking its therapeutic benefits. Seeing the need for viable alternatives, Homegrown Cannabis Co. created high-CBD strains. These are highly medicinal without inducing mind-altering effects.
Healing Without the High
THC and CBD are essential cannabinoids found in cannabis, and both have immense therapeutic benefits. What differentiates the two, though, is how it affects the mental state.
Tetrahydrocannabinol is a mind-altering compound that induces a euphoric high, whereas cannabidiol is non-psychoactive in nature. Hence, patients seeking to take advantage of cannabis' healing properties without getting intoxicated are better off opting for CBD-rich strains as it heals without the high. However, it is erroneous to equate CBD's medicinal effects as identical to THC. Despite the similarity, the two compounds affect the body differently.
THC vs. CBD
THC primarily binds with CB1 receptors, where it affects and regulates cognition, memory, sleep, mood, appetite, motor movement, and pain. That said, THC is mostly used to remedy conditions such as:
- Chronic and severe pain
- Muscle spasticity
- Lack of appetite
On the flip side, the level of THC intake must be monitored carefully as excessive amounts can cause unwanted side effects such as:
- Dizziness and headaches
- Temporary memory loss
- Impaired cognition
- Loss of balance and motor coordination
- Dry eyes
Meanwhile, CBD binds with CB2 receptors, although the affinity tends to be low at times. So, the more reliable route is to indirectly interact with the endocannabinoid system (ECS) by modulating anandamide, adenosine, serotonin, and vanilloid receptors. In effect, it mostly affects wakefulness, mood regulation, pain perception, and many vital neurological processes, making it useful in alleviating conditions like:
- Psychosis and other mental disorders
Besides being non-intoxicating, CBD is well-tolerated by the body, even in high amounts. Aside from the usual cottonmouth and dry eyes, it has no other known side effects.
To err on the side of caution, though, immunocompromised patients must be dissuaded from taking in too much CBD because of its potent anti-inflammatory properties. While this is beneficial in treating conditions like arthritis in which it suppresses excessive inflammation, this can further decrease the immunocompromised patient's defense against pathogens. Thus, it may increase vulnerability to microbial infections.
Medical Benefits of High CBD
Cannabidiol is usually the prevailing choice of medicinal patients because aside from being non-psychoactive, it is largely devoid of adverse effects. More importantly, research-backed evidence attests to its touted medicinal properties.
CBD can be an effective remedy against seizures due to its potent anti-convulsive properties. Clinical trials have proven its ability to reduce seizures in patients with Dravet and Lennox-Gastaut syndrome by approximately 50%. Hence, it is safe to say that CBD is a promising viable long-term treatment option for seizures. In fact, the US FDA has already approved the use of Epidiolex - an oil-based CBD formulation derived from Cannabis sativa.
- Anti-depressant and Anxiolytic
According to neuroscientists, brain cell regeneration is a process mediated by serotonin. Hence, low serotonin levels suppress this restorative mechanism, which eventually becomes a precipitating factor of developing depression and anxiety.
CBD helps alleviate these conditions through the activation of the 5-HT1A receptors, which stimulates the production and inhibits the reuptake of serotonin. In effect, this increases the serotonin levels available in the synaptic cleft.
CBD counteracts the psychotic-like symptoms induced by THC through antagonist mechanisms in the endocannabinoid receptors. Moreover, clinical trials reveal that CBD is immensely useful in managing the symptoms of schizophrenia - therefore making it an effective adjunct treatment for psychotic disorders.
CBD - through its combined immunosuppressive and anti-inflammatory actions - exhibits potent anti-arthritic effects. It suppresses prostaglandin production and lymphocyte proliferation - thereby subduing inflammation.
Cannabidiol alleviates pain by modulating vanilloid and glycine receptors, which play essential roles in nociceptive perception. It also prevents the reuptake of anandamide - a naturally-occurring endocannabinoid associated with pain regulation. Consequently, the increased levels of anandamide in the bloodstream and synaptic cleft reduces the amount of pain a person feels.
Apoptosis is the cell's self-destruct mechanism that prevents uncontrolled cell division. Impaired apoptosis leads to tumor growth and, eventually, cancer. CBD exhibits antiproliferative properties by interfering with tumor neovascularization, cancer cell migration, adhesion, invasion, and metastasization. It also inhibits the development of human breast cell carcinoma.
In contrast to its stimulating counterpart, CBD is known for calming effects. Hence, it comes as no surprise that it is useful as a vasorelaxant. In essence, it relaxes and dilates the blood vessels, which makes it easier for the blood to flow through, thus reducing hypertension.
4 Best High CBD Strains
Homegrown Cannabis Co., a firm believer in the medicinal value of cannabis, makes premium high-CBD seeds easily accessible. After all, home cultivation does not only guarantee a stable supply, but it also ensures that the harvested buds are free from pesticides and harmful chemicals.
The CBD to THC ratio of medical strains has an impact on its effects. Generally, varieties that have 1% THC or less do not exert psychoactive effects. On the other hand, those that have a 1:1 ratio would produce a high ranging from barely noticeable to mellow.
- CBD ACDC (CBD: 18-20% / THC: 1%)
CBD ACDC is a staple among patients in need of profound therapeutic effects with little to no cerebral high. Featuring an outstanding 20:1 CBD to THC ratio, it effectively alleviates anxiety, depression, deep-seated pain, inflammation, nausea, and even seizures.
Offered at Homegrown Cannabis Co. as feminized seeds, CBD ACDC's superior lineage ensures nothing but top-quality medical-grade yields. When given plenty of pampering, it achieves its full potential and produces 650 grams of resinous buds per square meter after 10 weeks of flowering. Outdoor cultivation is also an option. When exposed to plenty of sunlight, each plant yields up to 500 grams of gluey nugs.
- Carmen 2.0 (CBD: 13-20% / THC: 1-9%)
The mandarin-flavored Carmen 2.0 is not only a delight to the taste buds but also mental and physical well-being. Boasting of a 2:1 CBD to THC ratio, this strain melts away worries, sharpens focus, enhances the mood, and eases physical discomfort. And, it does so while exerting barely perceptible psychoactive effects.
Homegrown Cannabis Co.'s feminized Carmen 2.0 seeds ensure a straightforward cultivation process by eliminating the chance of sprouting males. Apart from that, it is also fast-flowering and average-yielding. After 7 to 9 weeks, expect to harvest 300-350 grams of buds per square meter. Outdoors, each sun-grown plant yields 350 grams of citrusy buds.
- CBD Harlequin (CBD: 18% / THC: 1%)
CBD Harlequin is the epitome of what medicinal cannabis should be. Its extraordinary CBD to THC ratio of 18:1 relieves stress, anxiety, and chronic pain in an instant. Even better, it heals and promotes calmness without mind-altering effects or sedation - thereby allowing one to remain functional and clear-headed while medicating.
Available as feminized seeds at Homegrown Cannabis Co., this strain is reasonably challenging to rear. Nonetheless, the efforts will be well worth it once it blooms and produces 400 grams of resin-caked buds per square meter. Meanwhile, outdoor cultivation is encouraged in places with a Mediterranean climate, for it provides more substantial yields. When grown under the sun, each plant yields 400 grams of medical-grade buds.
- CBD Haze (CBD: 10% / THC: 10%)
A tempered version of the well-loved Haze, CBD Haze is perfect for medicating patients who do not mind basking in a gentle euphoric high. This strain provides solace for the mind and painless experience for the body with a significantly subtler haziness. In particular, it is valued for its stress-relieving and pain-killing prowess along with potent anti-depressant and anxiolytic properties.
Cultivating feminized CBD Haze seeds from Homegrown Cannabis Co. is as straightforward as it can be. Since there is no need to discard males, one does not need to exert extra effort in identifying the gender of the plant. And, despite the long flowering period of 10 to 12 weeks, one could assure a massive harvest of 550 grams of trichome-glazed buds per square meter.