In the last decades, the cannabis scene is mostly dominated by strains that contain insane levels of THC. Although studies have shown its efficacy as an alternative treatment to many conditions, it is also responsible for the psychoactive traits. Disregarding issues on its legality, the fact that it causes the “high” is reason enough to inhibit many patients from taking advantage of its therapeutic benefits.
Recognizing the need for viable alternatives, the breeders of Homegrown Cannabis Co. have worked on developing mirror-opposites of modern strains. These are new generations of medical cannabis that contain substantial CBD levels, many of which have negligible or non-existent psychedelic effects. Moreover, these are available as regular, feminized, auto-flowering, and fast version seeds to suit the needs of all medical home growers.
Using high CBD medical strains is not without merits - as shown by numerous studies. The same holds true for THC (although it is psychoactive).
The efficacy of cannabis resides in its chemotype, of which CBD and THC are only two of many compounds working in synergy with each other. On note, too, is that the two primary compounds provide mostly different benefits. Patients should not mistake generalizing high CBD strains as “cannabis without the high” and expect benefits it could never provide.
CBD, like THC, binds with both CB1 and CB2. These are endocannabinoid system receptors affecting neurotransmitters sending messages throughout the body to maintain homeostasis. It appears that THC binds with CB1, found mostly in the part of the brain that controls critical functions including cognition, memory, motor, and pain. On the other hand, CBD interacts with CB2 found predominantly in the immune, gastrointestinal, and nervous systems as well as the brain. The mechanisms involved in these interactions remain vague. Even so, the positive benefits of CBD are evident in many studies conducted throughout the years.
For decades, activists advocated the legalization of cannabis, arguing that it has numerous medicinal uses. The campaign received a boost when the US FDA approved Epidiolex - an oil-based liquid formulation of CBD derived from Cannabis sativa. In particular, this drug is a treatment for seizures associated with Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS). Evidence of the efficacy of CBD can be found here and here.
One of the latest studies published in 2019 reveals:
The researchers concluded that add-on CBD could be a viable long-term treatment option for patients suffering from DS and LGS.
On its potential for pain relief, that is a fact that humans have known since ancient times. Science, however, is merely providing documented pieces of evidence relatively recently. For example, it is in this 2017 study that showed the efficacy of CBD in inhibiting pains and blocking acute inflammatory flares driving osteoarthritis. The following are merely two of many conditions that this beneficial compound could help alleviate.
In 2016, a study published in the European Journal of Pain investigated the efficacy of CBD in mitigating the symptoms of arthritis using rats. The dosages administered were 0.6, 3.1, 6.2, and 62.3 mg per day using CBD gels applied on affected joints. Highlights of this study showed:
Although it requires human studies, the results give credence to anecdotal evidence suggesting CBD is effective in treating or mitigating pain.
The use of CBD with regards to cancer is on two fronts - one in treating the disease, the other in mitigating the symptoms. In either case, the research is in its infancy stage. A recent review published in the Bosnian Journal of Basic Medical Sciences aimed to raise the understanding of the anticancer effects of cannabis. Based on prevailing literature, it appears that cannabinoids could affect essential cellular processes and signaling pathways crucial to the development of tumor by targeting the endocannabinoid system. Thus, it could induce cell cycle arrest, promote apoptosis, and inhibit proliferation, migration, and angiogenesis in tumor cells. One study, in particular, has given much hope to the seemingly impossible task of stopping cancer once and for all. It involved combining the use of CBD and chemotherapy on mice with pancreatic cancer in which the survival rate is three times longer than without the use of CBD. It can be further affirmed by another study in which the data gathered showed CBD itself may better prevent the growth and induce death of cervical cancer cells. A more plausible use of CBD is as a means to mitigate the symptoms of the disease and side effects of chemotherapy which includes pain, vomiting, and loss of appetite.
Homegrown Cannabis Co. understands the needs of people growing medical cannabis at home. Hence, in developing these high CBD strains, the importance of other traits that make the overall experience positive was considered. These include the efficacy of the therapeutic effects, the reliability of the genetics, and superb growth patterns to make growing at home a fun experience.
One of the commonalities of these high CBD strains is that the level of cannabidiol might help reduce seizures. Another is that it is unlikely that any could cause severe adverse reactions such as anxiety or paranoia